Knowledge Base

Schizophrenia and dendritic spines

Pyramidal neurons are the primary type of cells in the cerebral cortex; they are made of a cell body called soma, a single axon, an apical dendrite, multiple basal dendrites, and dendritic spines (Megias et al., 2001). Dendritic spines are small neuronal protrusions rising from a neuron’s dendrites; they typically receive excitatory input from one … Read More

The role of the frontal association cortex

The cerebral cortex can be divided into three main parts: the sensory areas, the motor areas, and the association areas. The association cortex is a complex distributed network, receiving information from the primary and secondary sensory and motor areas, as well as the brainstem and the thalamus, processing it, and sending it across multiple pathways … Read More

Schizophrenia and dopamine

Schizophrenia is a mental disorder causing a range of psychological symptoms such as delusions, hallucinations, disordered thinking, and abnormal motor behaviour, and which is considered by many as a neurodevelopmental disorder (Murray & Lewis, 1987; Weinberger, 2003). It affects 0.5–1% of the worldwide population, with a common onset in late adolescence to early adulthood (Perälä … Read More

How drugs impact the neurotransmitter life cycle

Neurons interact with each other through electrical events called action potentials and the release of chemical signals called neurotransmitters (Lodish et al., 2000). The neurotransmitter life cycle can be broken down into six component processes: synthesis, storage, release, receptor interaction, reuptake, and degradation (Beckstead, 1996). Each of these steps can be impacted by drugs in … Read More

The origins of the monoamine hypothesis of depression

Depression is a mental disorder characterised by clinical symptoms including low mood, rumination, functional impairment, retardation, and somatic syndromes such as sleep disturbances and loss of appetite (Lorr et al., 1967). Antidepressants were serendipitously discovered in the 1950s, when Iproniazid, a drug originally prescribed as a treatment for tuberculosis, was shown to induce increased vitality … Read More

Your brain on cortisol

In humans, stress can be defined as an actual or anticipated disruption of homeostasis in an individual (Ulrich-Lai & Herman, 2009). The brain plays a central role in the experience of stressful events and the regulation of stress: it adapts to stress both functionally and structurally, and dictates how individuals cope with stress (McEwen & … Read More

What’s the impact of deinstitutionalisation on patient outcomes?

Deinstitutionalisation – which can be defined as the diversion of people with a mental disorder to community mental health services, reducing the population of psychiatric hospitals, the number of psychiatric bed-days, and broadening the responsibilities of other service entities such as general hospitals and residential care (Bachrach, 1989) – started in Italy in the 1960s … Read More

Randomised controlled trials in psychotherapy research

Randomised controlled trials (RCTs) are considered one of the most rigorous and scientific methodologies to determine whether a cause-effect relationship exists between treatment and outcome, allowing researchers to exclude the possibility that the association was caused by an alternative factor (Sibbald & Roland, 1998). The random allocation to intervention groups, or randomisation, renders the groups … Read More

Theory of mind and autism spectrum disorder

Theory of mind (Premack & Woodruff, 1978) is the ability to understand the contents of another person’s mind, including their knowledge, emotions, beliefs, and intentions (Kloo et al, 2010). It is essential for social cognition (Astington & Edward, 2010), referential communication (Sidera et al, 2018), and better theory of mind is associated with better social interaction skills … Read More